Research philosophy at the Integrative Systems Biology Lab
Our research aims to develop large-scale, computer-aided models of
biological signaling, transcription regulatory networks and regulatory
pathways. We apply new experimental strategies and statistical
frameworks with the aim to integrate, model, and visualize the enormous
amount of measurements derived from genome-wide experiments such as
ultra-high-throughput DNA and RNA sequencing, proteins and mRNAs
expression, and protein-protein interactions arising in the wake of the
Human Genome Project. These tools are crucial to the success of systems
biology, an approach that aims to understand biological systems as more
than merely the sum of their parts.
We study biological sequences and how these are regulated in the context
of an entire system. We conduct bioinformatics and experimental research
by applying genome-scale approaches to derive and test network models
of complex systems such as the transcription regulation in higher
organisms. We are focusing of on climate change impact the evolution of Coral Reef animals in the Red Sea