Kondethimmanahalli Chandramouli

Postdoctoral Fellows

Research Interests

Chandra research interest includes larval settlement and metamorphosis, climate change and  biofouling. He is using 'omics’ technologies (proteomics and transcriptomics) to identify genes/proteins/molecular pathways in barnacles, polychaetes and oysters. His current research focused on understanding the proteomic patterns of Red Sea Barnacles larvae. He is also examining the reproductive patterns in polychaete Neanthes. His collaborative research is focused on the effect of ocean acidification in oyster larvae. While little is known about these species in Red Sea Arabian Peninsula and South China Sea (Hong Kong coast), his research helps elucidate the adaptation strategy of these species to extreme marine environment. His cross-disciplinary nature of research can serve as model for better understanding the effect of climate change on marine invertebrates.

Selected Publications

  • KH Chandramouli,  Taewoo  Ryu,  Huoming Zhang, Yanal Ghosheh, Sarah Al-Aqeel, Pei-Yuan Qian, Timothy Ravasi. Transcriptomic and proteomic shift reveals mechanisms of adaptation in larvae of Red Sea barnacle Balanus amphitrite. Molecular Ecology. "under review"
  • KH Chandramouli, PY Qian, T Ravasi . Proteomics Insights: Proteins related to Larval Attachment and Metamorphosis of Marine Invertebrates.  Frontiers in Marine Science (Marine Molecular Biology and Ecology). ISSN: 2296-7745. "In Press".
  • Y Zhang, S Jin, H Zhang, KH Chandramouli, Y Xu, LS  He, T Ravasi , PY Qian (2014) Proteomic profiling during pre-competent to competent transition of the biofouling polychaete Hydroides elegans. Biofouling. 30, 921-928.
  • Joy Mukherjee, Kelvin K.W. Wong, Chandramouli KH, Pei-Yuan Qian, Priscilla T. Y. Leung, Rudolf S.S. Wu and Vengatesen Thiyagarajan. (2013). Proteomic response of marine invertebrate larvae to climate change conditions during metamorphosis and calcification. The Journal of experimental Biology. 216, 4580-4589.
  • Jin Sun, Huawei Mu, Huoming Zhang, Chandramouli KH, Pei-Yuan Qian, Chris Wong and Jian-Wen Qiu (2013). Understanding the regulation of estivation in a freshwater snail through iTRAQ-based comparative proteomics. Journal of Proteome Research. 12 (11), 5271–5280.
  • Chandramouli KH, Timothy Ravasi, Donald J. Reish, and Pei-Yuan Qian (2013) Proteomic changes between male and female worms of the polychaetous annelid Neanthes arenaceodentata before and after spawning. PLoS ONE 8(8): e72990.
  • Chandramouli KH, Swagatika Dash,  Yu Zhang, Jin Sun, Jian-Wen Qiu, Timothy Ravasi , Pei-Yuan Qian (2013). Proteomic and metabolomic profiles of marine Vibrio sp. 010 in response to antifoulant challenge. Biofouling. 29 (7), 789–802.
  • Chandramouli KH, Flora SY Mok, Jin Sun, Lingli Liu, Jian-Wen Qiu, Timothy Ravasi , Pei-Yuan Qian (2013) Transcriptome and quantitative proteome analysis reveals molecular processes associated with larval metamorphosis in polychaete Pseudopolydora vexillosa. Journal of Proteome Research. 12, 1344−1358.
  • Chandramouli KH., Donald J. Reish and Pei-Yuan Qian. (2012) Gel-based and gel-free identification of proteins and phosphopeptides during egg-to-larva transition in polychaete Neanthes arenaceodentata. PLoS ONE, 7(6): e38814
  • #Swagatika Dash,#Chandramouli,KH, Yu Zhang and Pei-Yuan Qian. (2012). Effects of poly-ether B on proteome and phosphoproteome expression in biofouling Balanus amphitrite cyprids. Biofouling, 28(4),405-415. # Equal author contribution.
  • Chandramouli KH, Yu Zhang, Y. H. Wong, and Pei-Yuan Qian. (2012) Comparative glycoproteome analysis: Dynamics of protein glycosylation during larval attachment and metamorphosis in three invertebrates. Journal of Proteome Research, 11,1330−1340.
  • Chandramouli KH, Yu Zhang, Y. H. Wong, and Pei-Yuan Qian. (2011). Two-dimentional glycoproteome maps: A new insight in to protein glycosylation patterns during larval development and metamorphosis in marine invertebrates. Meeting abstract. Amino Acids, 41,S16.
  • Yi-Fan Zhang, Kang Xiao, Chandramouli KH, Ying Xu, Ke Pan, Wen-Xiong Wang and Pei-Yuan Qian (2011). Acute toxicity of the antifouling compound butenolide in non-target organisms.PLoS ONE,6(8), e23803.
  • Chandramouli KH, Lisa Soo and Pei-Yuan Qian. (2011). Proteome and   phosphoproteome analysis during larval development in polychaete Capitella sp. I. Proteome Science, 9, 51.
  • Chandramouli KH, Flora SY Mok, Wang Hao and Pei-Yuan Qian. (2011). Phosphoproteome analysis during larval development and metamorphosis in the spionidpolychaete pseudopolydora vexillosa. BMC Developmental Biology 11,31.
  • Beerelli Seshi, Kumaraguru Raja and Chandramouli KH. (2011). Immobilized pH Gradient–Driven Paper-Based IEF: A New Method for Fractionating Complex Peptide Mixtures Before MS Analysis. Clinical Proteomics 8:10.
  • Conference presentations
  • Chandramouli KH. International Conference on the Marine Environment of the Red Sea. 10 - 13 November 2014, Jeddah, Saudi Arabin.
  • Chandramouli KH. 13th Human Proteome Organization world Congress. 5-8 October 2014, Madrid, Spain. 
  • Chandramouli KH. 11th International Polychaete Conference, 4-9 August 2013, Sydney, Australia. 
  • Chandramouli KH. The 10th International Larval Biology Symposium. July 30-August 3, 2012, Berkely, California, USA.
  • Chandramouli KH. 7th Annual symposium, 6-7 January 2012, The University of Hong Kong, Hong Kong.
  • Chandramouli KH. International Conference on Genomics and Proteomics. 14 – 16 July 2011. Calicut, India.
  • Chandramouli KH. 12th International Congress on Amino acids, Peptides and Proteins. 1- 5 August, 2011. Beijing, China.
  • Chandramouli KH. 6th Annual symposium. 6-7 January 2011. The University of Hong Kong, Hong Kong.
  • Chandramouli  KH. The 9th Larval Biology Symposium. 23-27 August 2010. Wellington, New Zealand.


  • 2000-2004 Ph.D. - Department of Biochemistry, Mysore University, Mysore, India. Title of thesis: "Circumvention of multi-drug resistance in bacteria by phenoxazines."
  • 1996-1997    M.Sc. - Department of Biochemistry, Kuvempu University, Davangere, Karnataka, India.
  • 1993-1995    B.Sc. - majors in Biology and Chemistry, Kuvempu University, Government Science College, Chitradurga, Karnataka, India.