People

Prof. Timothy Ravasi

Principal Investigator
Professor of Bioengineering
KAUST Environmental Epigenetic Program (KEEP)
Division of Biological and Environmental Sciences & Engineering

Research Interests

Tim is working to develop large-scale, computer-aided models of biological signaling, transcription regulatory networks, and regulatory pathways. He applies new experimental strategies and statistical frameworks with the aim to integrate, model, and visualize the enormous amount of measurements derived from genome-wide experiments, such as ultra-high-throughput DNA and RNA sequencing, proteins and mRNAs expression, and protein-protein interactions arising in the wake of Genome Projects. These tools are crucial to the success of systems biology, an approach that aims to understand biological systems as more than merely the sum of their parts. He is also using Massively Parallel Genomes Sequencing to explore the biodiversity in the Red Sea Ecosystem such as reef fish and sponges, he is also interested on the affects of climate changes on the evolution and adaptation of reef animals.

Selected Publications

1. Timothy Ravasi, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B. Bajic, Kai Tan, etal. An atlas of combinatorial transcriptional regulation in mouse and man.Cell, 140-5, 744-752, 5 March 2010. (Faculty of 1000).

2. Harukazu Suzuki, Alistair R. R. Forrest, Erik van Nimwegen, Carsten O. Daub, Timo Lassmann, Timothy Ravasi et al. The transcriptional network that controls growth arrestand differentiation in a human myeloid leukemia cell line. Nat Genet. 2009 Apr19.

3. Tan K, Tegner J and Ravasi T. Integrated data-driven approaches to uncover transcription regulatorynetworks in mammalian cells. Genomics, 2008 Mar 91;3: 219-231 (Journal Cover and 2008 ScienceDirect TOP 5 HOTTEST ARTICLES).

4. Tegnér J, Nilsson R, Bajic VB, Björkegren J, and Ravasi T. Systems biology of innate immunity.Cell Immunol. 2006 Dec;244(2):105-9. (2007ScienceDirect TOP 10 HOTTEST ARTICLES)

5. Ravasi T, Wells C and Hume DA. Systems Biology of Transcription Control in Macrophages.Bioessays. 2007 Nov 15;29(12):1215-1226.

6. Nilsson R, BajicVB, Katayama K, Suzuki H, Reid JF, Sweet MJ, Gariboldi M, Carninici P, Hayashizaki Y, Hume DA, Tegner J, and Ravasi T. Transcriptional Network Dynamics governing Macrophage Activation, Genomics., 2006. 88, 2, 133-142.August 1. (2006 ScienceDirect TOP 10 DOWNLOADED ARTICLES)

7. Aung HT, Schroder K, Himes SR, Brion K, van Zuylen W, Trieu A, Suzuki H, Hayashizaki Y, Hume DA, Sweet MJ, and Ravasi T. LPS regulates proinflammatory gene expression inmacrophages by altering histone deacetylase expression. FASEB J., 2006. 20, 9.June 30. (2006 FASEB J., THE 20 MOST-FREQUENTLY DOWNLOADED ARTICLES)

8. Carninci P, Kasukawa T, Katayama T, Gough J, Frith M, Maeda M, Oyama M, Ravasi T, et  al. The Transcriptional Landscape ofthe Mammalian Genome. Science, 309:1559-1563, 2005. Faculty of 1000).

9. RavasiT, Suzuki H, Pang KC, Katayama S, Furuno M, Hume DA, and Mattick JS.Experimental validation of the regulated expression of a large numbers ofnoncoding RNAs from the mouse genome. Genome Research, 2006 Jan;16(1):11-9.

Education

1993-1996 B.Sc, Information Technology, University of Milan, Italy.
1996-1999 Doctorate, Information Technology, University of Milan, Italy.