Research Interests
Research Interests
Tim is working to develop large-scale, computer-aided models of
biological signaling, transcription regulatory networks, and regulatory
pathways. He applies new experimental strategies and statistical
frameworks with the aim to integrate, model, and visualize the enormous
amount of measurements derived from genome-wide experiments, such as
ultra-high-throughput DNA and RNA sequencing, proteins and mRNAs
expression, and protein-protein interactions arising in the wake of
Genome Projects. These tools are crucial to the success of systems
biology, an approach that aims to understand biological systems as more
than merely the sum of their parts. He is also using Massively Parallel
Genomes Sequencing to explore the biodiversity in the Red Sea Ecosystem
such as reef fish and sponges, he is also interested on the affects of climate changes on the evolution and adaptation of reef animals.
Selected Publications
1. Timothy Ravasi, Carlo Vittorio Cannistraci, Shintaro Katayama,
Vladimir B. Bajic, Kai Tan, etal. An atlas of combinatorial
transcriptional regulation in mouse and man.Cell, 140-5, 744-752, 5
March 2010. (Faculty of 1000).
2. Harukazu Suzuki, Alistair R. R. Forrest, Erik van Nimwegen, Carsten
O. Daub, Timo Lassmann, Timothy Ravasi et al. The transcriptional
network that controls growth arrestand differentiation in a human
myeloid leukemia cell line. Nat Genet. 2009 Apr19.
3. Tan K, Tegner J and Ravasi T. Integrated data-driven approaches to
uncover transcription regulatorynetworks in mammalian cells. Genomics,
2008 Mar 91;3: 219-231 (Journal Cover and 2008 ScienceDirect TOP 5
HOTTEST ARTICLES).
4. Tegnér J, Nilsson R, Bajic VB, Björkegren J, and Ravasi T. Systems
biology of innate immunity.Cell Immunol. 2006 Dec;244(2):105-9.
(2007ScienceDirect TOP 10 HOTTEST ARTICLES)
5. Ravasi T, Wells C and Hume DA. Systems Biology of Transcription
Control in Macrophages.Bioessays. 2007 Nov 15;29(12):1215-1226.
6. Nilsson R, BajicVB, Katayama K, Suzuki H, Reid JF, Sweet MJ,
Gariboldi M, Carninici P, Hayashizaki Y, Hume DA, Tegner J, and Ravasi
T. Transcriptional Network Dynamics governing Macrophage Activation,
Genomics., 2006. 88, 2, 133-142.August 1. (2006 ScienceDirect TOP 10
DOWNLOADED ARTICLES)
7. Aung HT, Schroder K, Himes SR, Brion K, van Zuylen W, Trieu A, Suzuki
H, Hayashizaki Y, Hume DA, Sweet MJ, and Ravasi T. LPS regulates
proinflammatory gene expression inmacrophages by altering histone
deacetylase expression. FASEB J., 2006. 20, 9.June 30. (2006 FASEB J.,
THE 20 MOST-FREQUENTLY DOWNLOADED ARTICLES)
8. Carninci P, Kasukawa T, Katayama T, Gough J, Frith M, Maeda M, Oyama
M, Ravasi T, et al. The Transcriptional Landscape ofthe Mammalian
Genome. Science, 309:1559-1563, 2005. Faculty of 1000).
9. RavasiT, Suzuki H, Pang KC, Katayama S, Furuno M, Hume DA, and
Mattick JS.Experimental validation of the regulated expression of a
large numbers ofnoncoding RNAs from the mouse genome. Genome Research,
2006 Jan;16(1):11-9.
Education
1993-1996 B.Sc, Information Technology, University of Milan, Italy.
1996-1999 Doctorate,
Information Technology, University of Milan, Italy.