Transcriptional Regulatory Networks

Transcriptional Regulatory Networks


Every molecular process occurring in a living cell is a concerted activity of numerous players. Networks defined by the interactions between genes and proteins perform specific cellular functions. A great challenge of modern biology is to elucidate these mechanisms and to decipher the dominant actors in these molecular networks. There are, however, numerous layers of interacting molecules and modern experimental and computational technologies have opened new possibilities for obtaining deeper insights into the intrinsic machinery governing the molecular interactions.

From a global point of view, one can consider the plethora of interacting molecules as a network of molecular entities that dynamically form under specific intra- and extra-cellular demands and execute their programmed actions accordingly. These networks are characterized not only by the participating molecular entities such as transcription factor (TFs) and their interactions with specific DNA binding sites (TFBS), but also by the direction and dynamics of the interactions.

From this perspective cellular networks are complex systems represented by numerous cause-consequence relationships.In our lab we adopt approaches that are based on the integration of Genome-wide measurements such as Transcriptomics and Proteomics in order to infer regulatory network of several eukaryote systems spanning from primitive multi-cellular eukaryotes such marine sponge to human.