Translational Genomics

Translational Genomics-Medicine


Translational genomics is the integrated application of innovative functional genomic tools and modern biophysical and clinical technologies to leverage maximum benefit out of vast amount of genome-scale datasets that are available in many experimental system including model organisms. Translational research is one of the most important aspects of translational medicine as it supports discovery of biomarkers in health and disease, probable drug targets that eventually leads to better understanding of the diseases and commercially exploitable diagnostic and therapeutic solutions. We combine expertise and infrastructure across various disciplines to support research on translational aspects of genomics. For example Genome-Wide Association Studies (GWAS) describe a very recent and emerging field that examines genetic variation across a given genome to identify genetic associations with phenotypic traits. More specifically, a dense array of genetic markers is typed from a set of DNA samples that are informative for a trait of interest.

The aim is to map susceptibility effects through the detection of associations between genotype frequency and trait status. In human studies, the first wave of large-scale, high-density GWAS increased our understanding of the underlying genetics related to several diseases such as Obesity and Diabetes.